derrierloisirs.fr
» » Congenital Chromosome Aberrations and Tumour Predisposition

Download Congenital Chromosome Aberrations and Tumour Predisposition ePub

by Gyorgy Fekete

Download Congenital Chromosome Aberrations and Tumour Predisposition ePub
  • ISBN 9630557533
  • ISBN13 978-9630557535
  • Language English
  • Author Gyorgy Fekete
  • Publisher Akademiai Kiado (January 1, 1995)
  • Pages 161
  • Formats mbr lrf lit mobi
  • Category Different
  • Subcategory Medicine and Health Sciences
  • Size ePub 1391 kb
  • Size Fb2 1716 kb
  • Rating: 4.9
  • Votes: 389


Congenital Chromosome Aberrations and Tumor Predisposition.

Congenital Chromosome Aberrations and Tumor Predisposition.

Congenital Chromosome Aberrations book. See a Problem? We’d love your help.

The chromosome aberration assay in vitro is a useful and sensitive test for detection of genotoxins. However, aberrations can occur secondary to toxicity, with compounds that do not react with DNA and are not genotoxic in vivo. Thus, some positive results in the in vitro aberration assay are not relevant to human risk.

Various types of chromosomal aberrations, including numerical (aneuploidy) and structural (. Here, we demonstrate that chromosome segregation errors can also result in structural chromosome aberrations. Aneuploidy is a direct consequence of chromosome segregation errors in mitosis, whereas structural aberrations are caused by improperly repaired DNA breaks. Here, we demonstrate that chromosome segregation errors can also result in structural chromosome aberrations

Wilms tumour is a primarily sporadic disease, with only 1–2 % of affected individuals having a relative with Wilms tumour

Wilms tumour is a primarily sporadic disease, with only 1–2 % of affected individuals having a relative with Wilms tumour  . The identification of the molecular defects that underlie these Wilms predisposition syndromes clarifies the risks of Wilms tumour risks and assists in the targeting of Wilms surveillance to those at increased risk.

In essence, structural chromosome aberrations are the result of chromosome breakage and abnormal reunion of broken chromosomes. They can be produced experimentally by exposing active cells to mutagens such as ionizing radiation. However, spontaneous structural rearrangements in both somatic and germ cells arise from errors of recombination.

Known as: Abnormalities, Chromosomal, Aberrations, Chromosomal, Aberration, Cytogenetic. An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), o. xpand. National Institutes of Health.

Aberration alters the chromosome structure but do not involve a change in chromosome number. The mechanics signify chiefly a rearrangement through loss, gain or reallocation of chromosomal segments.

It was first published in 1983 as a book named "Catalog of Chromosome aberrations in Cancer" in the Journal of Cytogenetics and Cell Genetics, containing 3,844 cases.