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Download Corynebacterium Parvum: Applications in Experimental and Clinical Oncology ePub

by Bernard Halpern

Download Corynebacterium Parvum: Applications in Experimental and Clinical Oncology ePub
  • ISBN 0306308371
  • ISBN13 978-0306308376
  • Language English
  • Author Bernard Halpern
  • Publisher Springer; 1 edition (October 1, 1975)
  • Pages 444
  • Formats lrf txt doc azw
  • Category Different
  • Subcategory Medicine and Health Sciences
  • Size ePub 1949 kb
  • Size Fb2 1911 kb
  • Rating: 4.1
  • Votes: 490

In his introduction to the Ciba Foundation Symposium on "Immunopotentia­ tion," Sir Peter Medawar stated that, "for the past twenty years the control of the immune response has been virtually equated to immunosuppression because the great goal of applied immunology has been the transplantation of tissues," and that, "with the discovery of tumor immunity-the focal point of immuno­ logical control has changed from immunosuppression to immunpotentiation and correspondingly the great prize of applied immunology has become the preven­ tion and control of malignant growth." Corynebacterium parvum is now univer­ sally recognized as being the most potent presently known immunopotentiator. C parvum is at the center of almost all papers presented at this conference and it has been analyzed from various viewpoints: taxonomy, pharmacology, immunopotentiation, stimulation of host resistance to tumor invasion in experi­ mental models and in human therapeutics. Almost all data reported in this volume are original and recently obtained. The discussions were spontaneous, stimulating, and highly enriching, and the results already established and re­ ported here are in many respects unique. Discussions at the conference revealed many other aspects which require further exploration. Nonspecific immunopotentiation has strongly penetrated into immunology, immunopathology, and, recently, oncology. Undoubtedly, this area of research will witness important developments in the near future. This book offers the first synthesis of presently available knowledge and emphasizes future prospects.

Corynebacterium parvum is now univer­ sally recognized as being the most potent presently known immunopotentiator. Corynebacterium Parvum. Applications in Experimental and Clinical Oncology.

Corynebacterium parvum is now univer­ sally recognized as being the most potent presently known immunopotentiator. C parvum is at the center of almost all papers presented at this conference and it has been analyzed from various viewpoints: taxonomy, pharmacology, immunopotentiation, stimulation of host resistance to tumor invasion in experi­ mental models and in human therapeutics. Almost all data reported in this volume are original and recently obtained. Almost all data reported in this volume are original and recently obtained

Corynebacterium parvum is now univer sally recognized as being the most potent presently known immunopotentiator.

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Corynebacterium parvum, a potent stimu-lator of the reticuloendothelial system, is one of a. .99 of Tada which are recorded elsewhere in the book

Corynebacterium parvum, a potent stimu-lator of the reticuloendothelial system, is one of a number of agents now being evaluated for " adjuvant immunotherapy of cancer ". Perhaps not surprisingly, a bewildering array of responses are produced in hosts treated with C. parvum, although activation of macrophages may be considered as o. 99 of Tada which are recorded elsewhere in the book. Dutton describes how he finds suppressor T cells in vitro, produced as a consequence of addition of concanavalin A. He feels that despite its artificiality the in vitro system, non-specifically induced, has much to offer a model of suppressive activity in vtvo.

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In a pilot study twelve patients with malignant disease were treated with Corynebacterium parvum

In a pilot study twelve patients with malignant disease were treated with Corynebacterium parvum. The clinical results were encouraging. Clinical progress is reported. Radiological, haematological, biochemical and immunological measurements have been made and these results are presented with emphasis on the immunological data

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Applications in Experimental and Clinical Oncology.

Action du Corynebacterium parvum sur les taux de lysozyme (muramidase) s~rique Effect of Corynebacterium parvum on serum lysozyme . Applications in experimental and clinical Oncology, . 7. Plenum Press, New York and London 1975.

Action du Corynebacterium parvum sur les taux de lysozyme (muramidase) s~rique Effect of Corynebacterium parvum on serum lysozyme (muramidase) levels G. Eliopoulosl, S. Andre, N. P. A n a g n o u l j. Meletis J et B. Halpern. lnstitut d'Immunobiologie de I ' I N S E R M et de l'Association Claude Bernard, Broussais, 96, rue Didot, Paris 14e (France), 9 octobre 1978 Summary. injection of 548 gg of killed Corynebacterium parvum into C57B1 mice leads to significant changes in serum lysozyme (muramidase) levels.