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Download Mitochondria and the Heart (Developments in Cardiovascular Medicine) ePub

by José Marín-García

Download Mitochondria and the Heart (Developments in Cardiovascular Medicine) ePub
  • ISBN 0387255745
  • ISBN13 978-0387255743
  • Language English
  • Author José Marín-García
  • Publisher Springer; 2005 edition (May 5, 2005)
  • Pages 400
  • Formats lit lrf docx doc
  • Category Medicine
  • Subcategory Medicine
  • Size ePub 1187 kb
  • Size Fb2 1215 kb
  • Rating: 4.4
  • Votes: 312

Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.

Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular .

Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics.

Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including .

Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis and degradation pathways are explored. José Marín-García is affiliated with The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey and the Department of Physiology & Biophysics, UMDNJ – Robert Wood Johnson Medical School, Piscataway, New Jersey. Show all. Table of contents (12 chapters). An Introduction to Mitochondria and the Heart.

Part of the Developments in Cardiovascular Medicine book series (DICM, volume . José Marín-García is affiliated with The Molecular Cardiology and Neuromuscular Institute, Highland Park, Ne. .

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 256). Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging.

Developments in Cardiovascular Medicine. Article · January 2004 with 6 Reads. The landscape of the practice of medicine is expected to change with the incorporation of the information content of the DNA sequence variants into the routine practice of medicine. How we measure 'reads'.

Электронная книга "Mitochondria and the Heart", José Marín-García. Эту книгу можно прочитать в Google Play Книгах на компьютере, а также на устройствах Android и iOS. Выделяйте текст, добавляйте закладки и делайте заметки, скачав книгу "Mitochondria and the Heart" для чтения в офлайн-режиме. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria .

Mitochondria and the Heart book. Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal The function of the heart is highly dependent on oxidative energy that is generated in mitochondria. Defects in mitochondrial structure and function can be found in association with cardiovascular diseases.

Mitochondria and the Heart discusses the role that mitochondria plays in.Series: Developments in Cardiovascular Medicine 256. File: PDF, 2. 0 MB. Czytaj online. Categories: Medicine.

Talk about Mitochondria and the Heart (Developments in Cardiovascular Medicine)


Isha
it is a basic and advanced nice review book of mitochondrial function. it may be old now. The writing is very readable and abeviations are indexed at the end and easy to understand. Only one problem is the price. Only people really loves mitichondria may buy.
Xig
The topics covered in this book are timely and should prove of great interest to researchers of both clinical cardiology and studies of cardiac physiology, molecular medicine and mitochondrial bioenergetics. The background presentations concerning mitochondrial ROS generation and mitochondrial genetics are particularly well-organized, provide current information and offer significant insights into the role of mitochondria in apoptosis, cardioprotection and aging. Finally, the discussion of future applications of mitochondrial medicine forecasts the enormous potential of this promising avenue of research.
Clandratha
This book offers a broad but complete overview of the world of mitochondria in the heart. The chapters are very brief but well based on recent data obtained from several reliable sources. The discussions are very objective and often do not lead to any argumentation which proves the impartiality of the author. Finally, I enjoyed reading the book and will definitely be waiting for an updated edition sometime in the future.